Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders – A retrospective analysis

These data demonstrate - for the first time - a link between an established peripheral marker of LGI and BCSFB permeability in schizophrenia. Platelets were found to be the main driver of the pLGI score regarding BCSFB permeability. Future research will need to replicate these findings and could explore whether measures of peripheral inflammation could be useful in the diagnostic work-up of patients with psychotic disorders.