Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

These findings confirmed the involvement of not only type 2 but also type 1 and type 3 immunity across all CHE patients, and demonstrate that IL-4Rα blockade may offer effective therapeutic perspectives for this highly burdensome condition, independent of an atopic dermatitis background.

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Publication Details

Journal
Allergy
Published
2026-02-18
DOI
https://doi.org/10.1111/all.70263
Primary Topic
Contact Dermatitis and Allergies
Type
article
Field-Weighted Citation Impact
0.00

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article

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Fatma Jendoubi, Lilian Basso, Marc Vocanson, Amel Bouznad et al.
Allergy
Contact Dermatitis and Allergies
article

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Fatma Jendoubi, Lilian Basso, Marc Vocanson, Amel Bouznad, Carle PAUL, M. Tauber, Vanina Lenief, Maria Polina Konstantinou, F. Hacard, Julien Sénéschal, Rüçhan Ekren, L. Jaulent, Juliette Mouiren, M. Boussier, P. Gery, M.A. Lefevre, Jonathan Rioual, C. Bulai Livideanu, Nadia Raison‐Peyron, A. Du‐Thanh, Emilie Bérard, Hugo Rimet, Audrey Nosbaum
article en

Abstract

These findings confirmed the involvement of not only type 2 but also type 1 and type 3 immunity across all CHE patients, and demonstrate that IL-4Rα blockade may offer effective therapeutic perspectives for this highly burdensome condition, independent of an atopic dermatitis background.

Allergy
Université Claude Bernard Lyon 1 (FR), École Normale Supérieure de Lyon (FR), Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), Université de Bordeaux (FR), Inserm (FR), Université Fédérale de Toulouse Midi-Pyrénées (FR), Université de Montpellier (FR), Centre Hospitalier Universitaire de Montpellier (FR), Hospices Civils de Lyon (FR), Hôpital Saint-André (FR), Hôpital Lyon Sud (FR), Hôpital Larrey (FR), Hôpital Saint Eloi (FR), Institut des Maladies Métaboliques et Cardiovasculaires (FR)
Sanofi, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
Openalex Percentile: Top 50%
Contact Dermatitis and Allergies
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