Angiotensin-(1–7) Activates Proopiomelanocortin Neurons in the Arcuate Nucleus
These findings suggest that angiotensin-(1-7) activates arcuate proopiomelanocortin neurons and engages arcuate-paraventricular inhibitory neurocircuits to lower blood pressure under normal conditions. In obesity, this circuit appears disrupted, which could contribute to the elevated blood pressure in this model.
Authors
- Amy Christine Arnold (ORCID: https://orcid.org/0000-0002-1380-6017)
- Sarah S. Bingaman
- Darren Mehay (ORCID: https://orcid.org/0000-0003-0058-3296)
- Katherine Kimbark
- Victoria Vernail
- Yuval Silberman (ORCID: https://orcid.org/0000-0002-4694-4053)
- Jordan Tanner
Institutions
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Hypertension
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1161/hypertensionaha.125.26262
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00