Effects of miR-451 on the proliferation, invasion and migration of papillary thyroid cancer cell line TPC-1 by regulating the PI3K/AKT/mTOR signaling pathway
miR-451 expression is significantly reduced in PTC tissues and TPC-1 cells. Overexpression of miR-451 inhibits proliferation, invasion, and migration in TPC-1 cells, likely via the PI3K/AKT/mTOR signaling pathway, suggesting its potential as a molecular target for further investigation in PTC.
Authors
- Qinghan Jiao
- Weizhen Chen
- Wei Yang
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1530/ec-25-0802
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00