Investigating the Role of KNG1 in Traumatic Brain Injury

Our transcriptomic analysis of TBI rat brain tissue identified KNG1 as a significantly upregulated gene functionally linked to the MAPK pathway, suggesting its potential role as an upstream regulator. Subsequently, in vitro functional validation demonstrated for the first time that KNG1 knockdown concurrently alleviated oxidative stress and suppressed MAPK hyperactivation. Therefore, this study not only defines a critical role for KNG1 in TBI pathology but also supports its potential as a therapeutic target that modulates multiple injury cascades.