HIF1A transcriptionally activates CDKN1A to drive ferroptosis in skeletal muscle ischaemia-reperfusion injury
Targeting the HIF1A-CDKN1A axis offers a promising therapeutic approach to reduce skeletal muscle damage and improve clinical outcomes after ischaemia-reperfusion injury.
Authors
- Yesheng Jin
- Jie Wu (ORCID: https://orcid.org/0000-0002-8566-6957)
- Zeqing Li (ORCID: https://orcid.org/0000-0002-6294-6243)
- Yunhong Ma
- Yuan Xue
- Yapeng Wang
- Hao Liu
- Yongjun Rui
- Peng Wang
- Xiaoyun Pan
- Kai Wang
- Ming Zhou
Institutions
- Soochow University (CN)
- The First People's Hospital of Changzhou (CN)
- Wuxi Ninth People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1016/j.jot.2026.101055
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00