E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model
Inactivation of <i>Cdh1</i> alone in <i>Cd44</i>-expressing cells is sufficient to induce DGC in mice. Tumour growth is significantly accelerated by concurrent <i>Trp53</i> inactivation.
Authors
- Parry Guilford (ORCID: https://orcid.org/0000-0002-7256-9576)
- Emily Schulpen
- Mik Black
- Nicola Bougen‐Zhukov (ORCID: https://orcid.org/0000-0001-9535-1150)
- Tanis Godwin (ORCID: https://orcid.org/0000-0002-2437-8556)
- Bostjan Humar (ORCID: https://orcid.org/0000-0002-7956-3062)
- Augustine Chen (ORCID: https://orcid.org/0000-0002-4063-2788)
- R. Van der Post
- Donghui Zou
- Amanda K. Charlton
- Kate L. McElroy
- Conor Vaessen
- Lyvianne Decourtye-Espiard
- José Garcia-Pelaez
Institutions
- Radboud University Nijmegen (NL)
- University of Auckland (NZ)
- University of Fribourg (CH)
- Universidade do Porto (PT)
- Radboud University Medical Center (NL)
- IPO Porto (PT)
- University of Otago (NZ)
Publication Details
- Journal
- Gut
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1136/gutjnl-2025-336182
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00