Single-cell atlas of hepatic cellular plasticity and immune niche reprogramming in liver cirrhosis
The analysis revealed three key axes influencing disease-related immune regulation: TNF-α/ETS2-driven polarization of macrophages toward a Mac-d phenotype, IL-1α/β/THRA-associated polarization of CD4<sup>+</sup> T cells toward a T4-c phenotype, and enhancement of the fibroblast-to-B-cell MIF signaling axis. This network offers valuable insights and potential therapeutic targets for advancing cirrhosis research and clinical treatment.
Authors
- Xiuli Kan
- Han Liu (ORCID: https://orcid.org/0000-0002-0014-4675)
- Zhicheng Zhang (ORCID: https://orcid.org/0000-0002-6711-6425)
- Nan Zhou
- Yi Fang
- Ying Chen
- Qing Zhang
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1186/s12967-026-07858-z
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00