Hyperthermia-targeted rectal delivery of thermosensitive liposomal doxorubicin via intra-arterial and intravenous administration
Intravenous and intra-arterial LTLD combined with localized rectal hyperthermia produced similar increases in rectal doxorubicin concentrations in a swine model. These findings support the feasibility of integrating thermosensitive liposomal drug delivery with localized rectal hyperthermia and intra-arterial catheter-based delivery.
Authors
- John W. Karanian (ORCID: https://orcid.org/0000-0002-0574-4231)
- Bradford J. Wood (ORCID: https://orcid.org/0000-0002-4297-0051)
- Rachel Ashe
- Michal Mauda‐Havakuk (ORCID: https://orcid.org/0000-0002-8810-3455)
- Ivane Bakhutashvili (ORCID: https://orcid.org/0000-0003-3706-1491)
- W. Pritchard
- Matthew F. Starost (ORCID: https://orcid.org/0000-0002-6234-4875)
- Keith T. Schmidt
- Dieter Haemmerich
- Reza Seifabadi
- Rochel Hecht
- William D. Figg
- Andrew S. Mikhail
Institutions
- National Institutes of Health (US)
- Medical University of South Carolina (US)
- Office of Research Services (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fphar.2026.1760944
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health