[18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation
<h2>Abstract</h2> Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([<sup>18</sup>F]FDG PET/CT) as [<sup>18</sup>F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [<sup>18</sup>F]FDG positive lesions that may initially appear metastatic.
Authors
- Marijn A. Vermeulen (ORCID: https://orcid.org/0000-0001-8926-1140)
- Annemieke Simone Littooij (ORCID: https://orcid.org/0000-0002-1839-0882)
- Pascal Kusters (ORCID: https://orcid.org/0000-0003-1343-4118)
- Manon S. Oud (ORCID: https://orcid.org/0000-0001-9513-3030)
- Jeanette van Leeuwen
- Arthur J.A.T. Braat
- Ronald R de Krijger
- Annelies M C Mavinkurve-Groothuis
- Luisa Queiró
- Caroline C.C. Hulsker
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Princess Máxima Center (NL)
Publication Details
- Journal
- EJC Paediatric Oncology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.ejcped.2026.100493
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting Kinderen Kankervrij