COMBI-EU: Real-World Evidence on Adverse Event Management and Time on Therapy with Adjuvant Dabrafenib Plus Trametinib in Patients with BRAF V600-Mutant Melanoma

High-level TRAE management showed a trend toward improved treatment adherence, which was statistically significant for pyrexia. Optional use of an app did not influence treatment adherence.

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Publication Details

Journal
Cancers
Published
2026-02-18
DOI
https://doi.org/10.3390/cancers18040667
Primary Topic
Melanoma and MAPK Pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

COMBI-EU: Real-World Evidence on Adverse Event Management and Time on Therapy with Adjuvant Dabrafenib Plus Trametinib in Patients with BRAF V600-Mutant Melanoma

Patrick Terheyden, E. Dippel, Dirk Debus, Rudolf Alexander Herbst et al.
Cancers
Melanoma and MAPK Pathways
article

COMBI-EU: Real-World Evidence on Adverse Event Management and Time on Therapy with Adjuvant Dabrafenib Plus Trametinib in Patients with BRAF V600-Mutant Melanoma

Patrick Terheyden, E. Dippel, Dirk Debus, Rudolf Alexander Herbst, Christoffer Gebhardt, Johannes Wohlrab, Yenny Angela, Michael Weichenthal, Manar Aoun, Magdalena Walecki, Tüting Thomas, Erwin Schultz, Fabian Ziller, L. M. Heinzerling, Anca Sindrilaru, Gaston Schley, P. Dücker, Ulrike Leiter, Nessr Abu Rached, Kjell M. Kaune, C.‐D. Klemke, R Stadler, Jens Ulrich, F Meier, Sebastian Haferkampf, Jochen Utikal, Imke von Wasielewski, Marc Bender, Dirk Schadendorf, Markus V. Heppt, Jessica C. Hassel, Peter Mohr, Lisa Zimmer
article en

Abstract

High-level TRAE management showed a trend toward improved treatment adherence, which was statistically significant for pyrexia. Optional use of an app did not influence treatment adherence.

CancersVol. 18(4)
Novartis (Switzerland) (CH), Universität Hamburg (DE), German Cancer Research Center (DE), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Heidelberg University (DE), Ludwigshafen University of Business and Society (DE), University Hospitals of the Ruhr-University of Bochum (DE), Dorothea Dix Hospital (US), University Hospital Heidelberg (DE), University Hospital Regensburg (DE), Christian-Albrechts-Universität zu Kiel (DE), Universitätsklinikum Erlangen (DE), Städtisches Klinikum Karlsruhe (DE), Nuremberg Hospital (DE), Helios Hospital Schwerin (DE), University Medical Center Hamburg-Eppendorf (DE), National Center for Tumor Diseases (DE), University Hospital Schleswig-Holstein (DE), Essen University Hospital (DE), Global Climate Forum (DE), University Cancer Center Hamburg (DE), Klinikum Dortmund (DE), Klinikum Ludwigshafen (DE), University Hospital Magdeburg (DE), Elbe Kliniken Stade-Buxtehude (DE), Helios Klinikum Erfurt (DE), Comprehensive Cancer Center Erlangen (DE), Klinikum Bremen-Mitte (DE), University Hospital Ulm (DE), University Medical Centre Mannheim (DE), University Hospital Carl Gustav Carus (DE), Klinikum Chemnitz (DE), Johannes Wesling Klinikum Minden (DE), Novartis Foundation (CH), Martin Luther University Halle-Wittenberg (DE), Technische Universität Dresden (DE), University of Tübingen (DE), Ludwig-Maximilians-Universität München (DE), Ruhr University Bochum (DE), University of Lübeck (DE)
Good health and well-being
Openalex Percentile: Top 51%
Melanoma and MAPK Pathways
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