Unveiling prognostic genes and regulatory mechanisms of stress granules in gastric cancers: an integrated analysis of bulk transcriptomics and single-cell RNA sequencing

In summary, we identified a four-gene SG-related signature strongly associated with prognosis in GC and constructed a predictive model with clinical potential. Our integrated analysis identified endothelial cells as a candidate population linked to the expression of these genes. These findings provide associative evidence linking SGs to GC outcomes and highlight potential targets for future mechanistic and therapeutic exploration.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-18
DOI
https://doi.org/10.3389/fonc.2026.1750088
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00

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article

Unveiling prognostic genes and regulatory mechanisms of stress granules in gastric cancers: an integrated analysis of bulk transcriptomics and single-cell RNA sequencing

Zhiwei Qin, Jiuhua Xu, Ruilong Kou, Bin Lan et al.
Frontiers in Oncology
Ferroptosis and cancer prognosis
article

Unveiling prognostic genes and regulatory mechanisms of stress granules in gastric cancers: an integrated analysis of bulk transcriptomics and single-cell RNA sequencing

Zhiwei Qin, Jiuhua Xu, Ruilong Kou, Bin Lan, Yuehua Chen, JINZHOU WANG, Chenyu Zhu
article en

Abstract

In summary, we identified a four-gene SG-related signature strongly associated with prognosis in GC and constructed a predictive model with clinical potential. Our integrated analysis identified endothelial cells as a candidate population linked to the expression of these genes. These findings provide associative evidence linking SGs to GC outcomes and highlight potential targets for future mechanistic and therapeutic exploration.

Frontiers in OncologyVol. 16
Fujian Medical University (CN), Guilin Medical University (CN), Dalian Medical University (CN), First Affiliated Hospital of Fujian Medical University (CN), First Affiliated Hospital of Dalian Medical University (CN)
Natural Science Foundation of Fujian Province
No poverty
Openalex Percentile: Top 50%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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Unveiling prognostic genes and regulatory mechanisms of stress granules in gastric cancers: an integrated analysis of bulk transcriptomics and single-cell RNA sequencing — Zhiwei Qin, Jiuhua Xu, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS