Kidney and Survival Outcomes with Semaglutide by CKD Severity in the FLOW Trial

Semaglutide reduced risks of major kidney disease events and all-cause death across wide-ranging categories of baseline eGFR and UACR, supporting semaglutide treatment in T2D throughout the spectrum of CKD severity represented in FLOW, including advanced CKD.Clinical Trial registry name and registration number: NCT03819153 .

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Publication Details

Journal
Clinical Journal of the American Society of Nephrology
Published
2026-02-18
DOI
https://doi.org/10.2215/cjn.0000000974
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Kidney and Survival Outcomes with Semaglutide by CKD Severity in the FLOW Trial

KW Mahaffey, Ole Kleist Jeppesen, Manuel Mayrdorfer, Janusz Gumprecht et al.
Clinical Journal of the American Society of Nephrology
Diabetes Treatment and Management
article

Kidney and Survival Outcomes with Semaglutide by CKD Severity in the FLOW Trial

KW Mahaffey, Ole Kleist Jeppesen, Manuel Mayrdorfer, Janusz Gumprecht, B. Rayner Rayner, Vlado Perkovic, Johannes F. E. Mann, Mustafa Arici, Peter Rossing, Naoki Kashihara, Ricardo Correa-Rotter, David Z.I. Cherney, Richard E. Pratley, Katherine R. Tuttle, Heidrun Bosch-Traberg, on behalf of the DAHLIAS study investigators, Giuseppe Pugliese
article en

Abstract

Semaglutide reduced risks of major kidney disease events and all-cause death across wide-ranging categories of baseline eGFR and UACR, supporting semaglutide treatment in T2D throughout the spectrum of CKD severity represented in FLOW, including advanced CKD.Clinical Trial registry name and registration number: NCT03819153 .

Clinical Journal of the American Society of Nephrology
University of Copenhagen (DK), Steno Diabetes Centers (DK), University of Cape Town (ZA), Medical University of Silesia (PL), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), University of Toronto (CA), Novo Nordisk (Denmark) (DK), Kawasaki Medical School (JP), Providence College (US), University of Washington (US), Toronto General Hospital (CA), Inland Northwest Health Services (US), Groote Schuur Hospital (ZA), UNSW Sydney (AU), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX), Translational Research Institute for Metabolism and Diabetes (US), Stanford Medicine (US), Center for Clinical Research (United States) (US), Hacettepe University (TR), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 53%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
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