Targeted Inhibition of mGlu5 Receptors in the Contralesional Hemisphere Improves Functional Recovery After Stroke
These findings demonstrate that the homotopic contralateral somatosensory cortex is a key site of action of systemic mGlu5 receptor NAMs in enhancing restorative processes important for recovery after stroke. Targeted, light-modulated drugs represent a potential future therapeutic strategy to enhance recovery of function after stroke.
Authors
- Serena Notartomaso (ORCID: https://orcid.org/0000-0003-4374-9233)
- Domenico Bucci (ORCID: https://orcid.org/0000-0003-3239-2435)
- G. Battaglia
- Karsten Ruscher (ORCID: https://orcid.org/0000-0001-7211-2499)
- Tadeusz W. Wieloch (ORCID: https://orcid.org/0000-0002-7669-2520)
- Amadeu Llebaria (ORCID: https://orcid.org/0000-0002-8200-4827)
- V. Bruno
- Adam Q. Bauer
- Ferdinando Nicoletti
- Slovianka Moyanova
- Xavier Gómez-Santacana
- Federica Mastroiacovo
Institutions
- Lund University (SE)
- Washington University in St. Louis (US)
- Istituto Neurologico Mediterraneo (IT)
- Institute of Advanced Chemistry of Catalonia (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Stroke
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1161/strokeaha.125.054261
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00