Two Distinct Transcriptional Subtypes of Severe Type 2 Asthma in <scp>NSAID</scp> ‐Exacerbated Respiratory Disease
Patients in cluster 1 exhibited T2 inflammation with low GATA3 expression, while those in cluster 2 showed T2 inflammation with high GATA3 expression. Sputum GATA3 expression may serve as a useful biomarker for differentiating distinct severe asthma subtypes in patients with N-ERD.
Authors
- Adam Ćmiel (ORCID: https://orcid.org/0000-0002-7015-1707)
- Lucyna Mastalerz (ORCID: https://orcid.org/0000-0002-8994-0036)
- Radosłąw Kacorzyk (ORCID: https://orcid.org/0000-0002-2778-2407)
- Marek Sanak
- Piotr Szatkowski
- Bogdan Jakieła
Institutions
- Jagiellonian University (PL)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1111/cea.70253
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki