Spatiotemporal Role of GLI2 in Driving SHH-Medulloblastoma Tumorigenesis
Our studies uncover the developmental origins and molecular mechanisms underlying GLI2-amplified SHH-MB. We also reveal that the MAPK pathway plays a critical role in GLI2-driven SHH-MB tumorigenesis and progression.
Authors
- Jianhua Yang (ORCID: https://orcid.org/0000-0002-6873-7653)
- Packer Rj
- Melanie Schoof (ORCID: https://orcid.org/0000-0002-1373-8130)
- Marina Grachtchouk (ORCID: https://orcid.org/0000-0003-4677-2834)
- Brian Rood
- Andrzej A. Dlugosz (ORCID: https://orcid.org/0000-0002-9791-3257)
- Najiba Murad
- Prathibhani Gamachchige Ramawickrama
- Ran Tao (ORCID: https://orcid.org/0000-0002-9962-1768)
- Xiao Liu (ORCID: https://orcid.org/0000-0002-0929-598X)
- Zhenhua Xu (ORCID: https://orcid.org/0000-0003-0919-545X)
- Qingshi Chen
- Yanxin Pei
- Michael D Taylor
- Ulrich Schüller
- Jiao Zhang
- Samuel Rivero-Hinojosa
- Huadong Pei
- Lakshmi Ramachandran Nair
Institutions
- St. Jude Children's Research Hospital (US)
- Children's National (US)
- Universität Hamburg (DE)
- Baylor College of Medicine (US)
- Georgetown University (US)
- George Washington University (US)
- Purdue University West Lafayette (US)
- Georgetown University Medical Center (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Kinderkrebs-Zentrum Hamburg (DE)
- Michigan Medicine (US)
- University Cancer Center Hamburg (DE)
- Texas Children's Hospital (US)
- Children's Cancer Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1093/neuonc/noag033
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00