Human Periodontal Ligament Transcriptomes Under Orthodontic Extrusion and Intrusion: An Exploratory Pilot <scp>RNA</scp> ‐Seq Study With an Interactive Public Web Tool

This exploratory pilot study presents a hypothesis-generating transcriptomic resource describing early (0-10 day) human PDL responses to orthodontic extrusion and intrusion and a publicly accessible web tool (HOTM) for convenient exploration of candidate genes and pathways. All findings should be interpreted as exploratory and require confirmation in independent, adequately powered cohorts with appropriate multiple-testing correction and orthogonal validation before mechanistic or clinical interpretation.