Chemokines CXCL9 and CCL2 in Relation to Cerebral White Matter Disease, Cognitive Decline, and Dementia

Greater CXCL9 levels were associated with greater white matter lesion load, independent of vascular, renal, and genetic factors, suggesting a role in WMD pathogenesis. WMHV mediated CXCL9's association with cognitive decline and dementia risk. This IFN-γ-induced monokine (MIG) warrants further evaluation as a biomarker of white matter and cognitive health as well as a potentially modifiable therapeutic target.

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Publication Details

Journal
Neurology Open Access
Published
2026-02-18
DOI
https://doi.org/10.1212/wn9.0000000000000065
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Chemokines CXCL9 and CCL2 in Relation to Cerebral White Matter Disease, Cognitive Decline, and Dementia

Emir Veledar, José Gutierrez, Hannah E. Gardener, Mohammad Nafeli Shahrestani et al.
Neurology Open Access
Neuroinflammation and Neurodegeneration Mechanisms
article

Chemokines CXCL9 and CCL2 in Relation to Cerebral White Matter Disease, Cognitive Decline, and Dementia

Emir Veledar, José Gutierrez, Hannah E. Gardener, Mohammad Nafeli Shahrestani, Christian Agudelo, Mitchell S. V. Elkind, Sarah E. Tom, Tatjana Rundek
article en

Abstract

Greater CXCL9 levels were associated with greater white matter lesion load, independent of vascular, renal, and genetic factors, suggesting a role in WMD pathogenesis. WMHV mediated CXCL9's association with cognitive decline and dementia risk. This IFN-γ-induced monokine (MIG) warrants further evaluation as a biomarker of white matter and cognitive health as well as a potentially modifiable therapeutic target.

Neurology Open AccessVol. 2(1)
American Heart Association (US), University of Miami (US), City University of New York (US), National Institute of Neurological Disorders and Stroke (US), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 60%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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Chemokines CXCL9 and CCL2 in Relation to Cerebral White Matter Disease, Cognitive Decline, and Dementia — Emir Veledar, José Gutierrez, et al. · Neurology Open Access (2026) | TGRS Research Map | TGRS