Treponema pallidum mRNA-LNP vaccine candidate encoding TP0954 induces strongly protective immunity in rabbits
Therefore, we successfully constructed a novel mRNA vaccine targeting TP0954 for syphilis and found superior immune protective effects compared with TP0954 recombinant protein vaccine, further confirming that TP0954 is a promising vaccine candidate for syphilis.
Authors
- Q Wang
- Jie Zhou (ORCID: https://orcid.org/0000-0003-3208-9073)
- Yanan Wu (ORCID: https://orcid.org/0000-0001-8326-2492)
- Zhiyu Lu
- Ruili Zhang
- Guoyang Liao
- Fangzhi Du
- Di Liu (ORCID: https://orcid.org/0000-0003-3693-2726)
- Yizhou Lu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Dermatology (TH)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Institute of Medical Biology (SG)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1769155
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Peking Union Medical College
- Bijzonder Onderzoeksfonds UGent