Hemoglobin A1c-systolic blood pressure index as a novel predictor of cardiovascular disease: evidence from three prospective cohorts
HSI, a simple composite of HbA1c and SBP, was consistently associated with incident CVD across three international cohorts. Its predictive ability exceeded that of HbA1c or SBP alone, highlighting it as a pragmatic tool for integrated cardiometabolic risk assessment. The findings warrant further clinical validation.
Authors
- Boyang Xiang (ORCID: https://orcid.org/0009-0007-7584-9390)
- Ruiqi Zhang (ORCID: https://orcid.org/0000-0002-3800-9065)
- Xuelian Chen
- Shushu Zhu
- Benjun Zhou
Institutions
- Jiangsu University (CN)
- First People's Hospital of Kunshan (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fendo.2026.1718936
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00