Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer’s disease
ApoE ε4 carriers demonstrate a distinct metabolic profile characterized by lower BMI and elevated TyG index, associated with poorer cognitive performance. Our findings suggest that ApoE ε4 may indirectly influence AD cognition through metabolic pathways, highlighting early interventions targeting ApoE-related metabolic dysregulation as potential strategies to delay AD progression.
Authors
- Zhaoyang Lv (ORCID: https://orcid.org/0000-0002-7788-9982)
- Cihan Di (ORCID: https://orcid.org/0000-0001-5328-1764)
- Shiyu Fan
- Feng Liu
- Shuai Liu
- Zhihong Shi
- Renyu Chen
- Yong Ji
- Hao Wu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin Huanhu Hospital (CN)
- Shangqiu First People's Hospital (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fnagi.2026.1731547
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Municipal Education Commission
- Tianjin Science and Technology Program