TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis
This study identifies TGM2 as a key regulator of AP macrophage efferocytosis via the novel TGM2-STAT6-GAS6 axis. LF-LNP@si-TGM2 is a promising targeted strategy for AP, potentially shifting treatment from supportive to precision therapy.
Authors
- Yuanhang He (ORCID: https://orcid.org/0000-0002-6439-4315)
- Ziang Meng
- Liyi Wang (ORCID: https://orcid.org/0000-0002-9454-8872)
- Xuxu Liu (ORCID: https://orcid.org/0000-0001-5408-4746)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Z.J. Xie
- Z Du
- Dongbo Xue
- Yi Zheng
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1002/advs.202520739
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Program of Heilongjiang
- National Natural Science Foundation of China