Heterogeneity and plasticity of the naive CD4+ T cell compartment
This study describes the transcriptional heterogeneity of murine and human naive CD4<sup>+</sup> T cells as comprising multiple discrete clusters that impact CD4<sup>+</sup> T cell fate and trajectories. Naive CD4<sup>+</sup> T cells experiencing inflammatory environments exhibit an altered transcriptional state that biases their differentiation trajectories.
Authors
- Evelien Schaafsma (ORCID: https://orcid.org/0000-0002-3821-3568)
- Walburga Croteau (ORCID: https://orcid.org/0000-0002-5318-5358)
- Mohamed ElTanbouly (ORCID: https://orcid.org/0000-0001-7985-3839)
- Elizabeth C. Nowak (ORCID: https://orcid.org/0000-0001-8791-6166)
- Mary Jo Turk (ORCID: https://orcid.org/0000-0002-9612-8329)
- Alia Sajani
- Christopher M. Burns
- J. Louise Lines
- Chao Cheng
- Randolph J. Noelle
Institutions
- Dartmouth College (US)
- Baylor College of Medicine (US)
- Dartmouth Psychiatric Research Center (US)
- Rockefeller University (US)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.celrep.2026.116980
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00