Clinical impact of adherence to a standardized treatment algorithm for idiopathic sudden sensorineural hearing loss: a multicenter cohort study

In this multicenter cohort, adherence to a standardized algorithm was moderate but was associated with improved hearing outcomes. In severe SSNHL, intravenous steroids enhance the early response-most notably in Grade 3-while salvage intratympanic steroid therapy considerably improves the final recovery rate. These findings support the implementation and optimization of the algorithm as well as the refinement of systemic dosing. Additionally, they highlight the importance of structured, guideline-based management in routine practice to improve outcomes in real-world SSNHL care.

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Publication Details

Journal
Frontiers in Neurology
Published
2026-02-18
DOI
https://doi.org/10.3389/fneur.2026.1775755
Primary Topic
Vestibular and auditory disorders
Type
article
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article

Clinical impact of adherence to a standardized treatment algorithm for idiopathic sudden sensorineural hearing loss: a multicenter cohort study

Ryosuke Kitoh, Yutaka Takumi
Frontiers in Neurology
Vestibular and auditory disorders
article

Clinical impact of adherence to a standardized treatment algorithm for idiopathic sudden sensorineural hearing loss: a multicenter cohort study

Ryosuke Kitoh, Yutaka Takumi
article en

Abstract

In this multicenter cohort, adherence to a standardized algorithm was moderate but was associated with improved hearing outcomes. In severe SSNHL, intravenous steroids enhance the early response-most notably in Grade 3-while salvage intratympanic steroid therapy considerably improves the final recovery rate. These findings support the implementation and optimization of the algorithm as well as the refinement of systemic dosing. Additionally, they highlight the importance of structured, guideline-based management in routine practice to improve outcomes in real-world SSNHL care.

Frontiers in NeurologyVol. 17
Shinshu University (JP), Ōtani University (JP)
Good health and well-being
Openalex Percentile: Top 60%
Vestibular and auditory disorders
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