Temporal trends in stroke-prevention medication use in patients with atrial fibrillation and chronic obstructive pulmonary disease
Nationwide real-world data demonstrated a dramatic shift over the past decade in stroke-prevention strategies among patients with coexisting COPD and AF, moving from warfarin- or OAPT-based therapy to predominantly NOAC-based therapy. Ischemic stroke and major bleeding were decreased over the calendar years. COPD exacerbation history did not alter stroke-prevention medication use, though this subgroup warrants attention due to elevated cardiovascular risks.
Authors
- Nantawarn Kitikannakorn
- Chuan-Wei Shen (ORCID: https://orcid.org/0000-0003-4503-5795)
- Buntitabhon Sirichanchuen (ORCID: https://orcid.org/0000-0003-2278-4099)
- Chung‐Yu Chen (ORCID: https://orcid.org/0000-0001-9002-7255)
- Rewadee Jenraumjit (ORCID: https://orcid.org/0000-0003-4534-8046)
- Kung-Ming Laio
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Min-Hwei College of Health Care Management (TW)
- Center for Assessment (US)
- Chi Mei Medical Center (TW)
- Chiang Mai University (TH)
- Massachusetts Department of Mental Health (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fphar.2026.1761934
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00