Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation
Multi-cohort, single-cell RNA-seq, and experimental data collectively suggest MTURN as a trained immunity-related biomarker for the diagnosis of heart failure with a potential link to PIEZO1-mediated cardiac remodeling.
Authors
- Guo‐Chang Fan (ORCID: https://orcid.org/0000-0002-0439-8277)
- Xiaohong Wang (ORCID: https://orcid.org/0000-0002-4558-7349)
- Wei Huang (ORCID: https://orcid.org/0000-0003-2921-3918)
- Tianyuan Yang (ORCID: https://orcid.org/0000-0003-4219-837X)
- Nebahat Ece Kesten
- Tianqing Peng
- Zhixin Li
- Mingliang Pan
Institutions
- Western University (CA)
- Ondokuz Mayıs University (TR)
- London Health Sciences Centre (CA)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1739660
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00