Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study

This study developed a fully automated quantification model for the spatial distribution of whole-liver fat. Characterization of the spatial heterogeneity of hepatic fat accumulation provides additional, phenotypically relevant information across SLD subcategories. These findings highlight the clinical utility of spatial heterogeneity as a novel, noninvasive imaging biomarker for subtype identification and personalized disease assessment of SLD. Moreover, this automated framework offers a scalable and objective tool for future longitudinal monitoring.