Human vagus nerve fascicular anatomy and its implications for targeted cardiac stimulation: a microCT segmentation and histological pilot anatomical study
Notably, the superior cardiac branch on both sides remained distinct near the typical vagus nerve stimulation cuff site, highlighting potential for targeted cardiac neuromodulation potentially relevant to conditions including myocardial infarction, heart failure, and atrial fibrillation. These findings advance understanding of human vagus nerve organization and support the design of selective stimulation strategies for precise autonomic regulation.
Authors
- Kirill Aristovich (ORCID: https://orcid.org/0000-0002-2924-5680)
- Paul Robert Shearing (ORCID: https://orcid.org/0000-0002-1387-9531)
- Svetlana Mastitskaya (ORCID: https://orcid.org/0000-0002-4819-2908)
- David Holder (ORCID: https://orcid.org/0000-0003-2755-6124)
- F. Iacoviello
- Nicole Thompson
- Felicia Turhani
Institutions
- Biochemical Society (GB)
- University College London (GB)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fnins.2026.1731234
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cambridge
- Scheme for Promotion of Academic and Research Collaboration
- National Institutes of Health
- Medical Research Council