AMPK-dependent maturation of hiPSC-derived cardiomyocytes induced by human cardiac fibroblast exosomes
hc-FB-EXOs promote the maturation of hiPSC-CMs via AMPK-mediated metabolic reprogramming and enhance their therapeutic benefit after MI. Cardiac fibroblast-derived exosomes may serve as a practical adjunct to optimize hiPSC-CMs-based therapy for ischemic cardiomyopathy.
Authors
- Xun Wu (ORCID: https://orcid.org/0000-0002-0620-8641)
- Jinfu Yang (ORCID: https://orcid.org/0000-0001-5037-0745)
- Kun Xiang (ORCID: https://orcid.org/0000-0001-8168-1773)
- Chengming Fan
- Kele Qin
- Xiaohui Xie
- Xiuneng Li
- Huatao Zhou
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Clinical and Experimental Hypertension
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1080/10641963.2026.2631601
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00