Major adverse cardiovascular and bleeding outcomes in paroxysmal vs. non-paroxysmal atrial fibrillation: an individual patient-level data analysis of a large cohort of patients from the COMBINE-AF
Compared to non-PAF, adjusted risks in PAF patients were lower for stroke/systemic embolic event and all-cause death, and higher for major or clinically relevant non-major bleeding and myocardial infarction.These findings highlight clinically important differences in outcomes by AF type that may have clinical applications for AF patients.
Authors
- Anthony Carnicelli (ORCID: https://orcid.org/0000-0002-9805-4562)
- Michael G. Palazzolo
- Christian Ruff
- Christopher B. Granger
- John Eikelboom
- Kenneth W. Mahaffey
- Andreas Goette
- Robert P. Giugliano
- George Ntaios
- Manesh Patel
- Mark S. Link
- Lars Wallentin
Institutions
- Uppsala University (SE)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Medical University of South Carolina (US)
- Duke University (US)
- AHEPA University Hospital (GR)
- Clinical Research Institute (US)
- Stanford Medicine (US)
- Center for Clinical Research (United States) (US)
- Thrombolysis in Myocardial Infarction Study Group (US)
- The University of Texas Southwestern Medical Center (US)
- Otto-von-Guericke-Universität Magdeburg (DE)
- McMaster University (CA)
Publication Details
- Journal
- European Journal of Internal Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.ejim.2026.106774
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00