Dysfunctional decidual CD2+CD4+T cells regulated by Rev-erbα - GFPT1 - GPI anchored CD58 axis of decidual stromal cells underlies sleep disturbance induced recurrent pregnancy loss

Rev-erbα - GFPT1 - CD58 - CD2 axis played important role in pregnancy maintenance by regulating the crosstalk between DSCs and decidual CD4⁺T cells. Given that poor sleep is a common problem during pregnancy, our findings may have important implications for understanding the etiology of RPL and developing targeted therapy of RPL. In addition, we should pay attention to the sleep health of pregnant women, especially those with a history of RPL.