Humoral immune responses to hyaluronan oligosaccharides in patients undergoing prosthetic valve surgery
Anti-HA antibodies are constitutively present in humans, undergo transient amplification after cardiac surgery, regardless of prosthesis type, and display marked fragment-length specificity. Short HA2 fragments predominate in ELISA responses, whereas intermediate-length oligomers, such as HA34, emerge as conserved, immunodominant targets in PGA. These findings extend the Translink paradigm from xenogeneic to matrix-derived glycan immunity and identify anti-HA antibodies as potential biomarkers of postoperative inflammation and tissue remodeling, which could be relevant to SVD.
Authors
- C. Galli
- Manuel Galiñanes (ORCID: https://orcid.org/0000-0002-0888-976X)
- Daniel Bello-Gil
- Vered Padler‐Karavani (ORCID: https://orcid.org/0000-0002-4761-3571)
- Arnau Blasco-Lucas (ORCID: https://orcid.org/0000-0002-2796-7428)
- Marta Vadori (ORCID: https://orcid.org/0000-0002-9763-2383)
- Emanuele Cozzi
- Jean-Paul Soulillou
- Rafael Máñez
- Tomaso Bottio
- J C Roussel
- Sara Olivera-Ardid
- Cristina Costa
- Thierry Le Tourneau
Institutions
- Hebron University (PS)
- University of Padua (IT)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Institut de Transplantation Urologie en Nephrologie (FR)
- Avantea (IT)
- Institut du Thorax (FR)
- Cellular Biomedicine Group (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1762676
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- School of Medicine, Emory University
- Instituto de Salud Carlos III