Integrated transcriptomic and functional analyses reveal that NOX2 inhibition rewires the inflammatory landscape of macrophages

Together, these results demonstrate that NOX2 inhibition does not broadly reprogram macrophages in the resting state but reshapes the inflammatory landscape of LPS-stimulated pro-inflammatory macrophages, shifting them toward a reparative, anti-inflammatory state even in the presence of strong activating stimuli. Our findings provide mechanistic insight into the immunomodulatory potential of NOX2 inhibition in inflammatory models.