Comparative efficacy and safety of anticoagulant, combination, and antiplatelet therapies in patients with intracardiac thrombus: a real-world retrospective study

In patients with intracardiac thrombus, anticoagulant monotherapy was associated with a significantly lower one-year all-cause mortality compared with antiplatelet therapy, whereas its effect on thrombus dissolution was attenuated after full adjustment, potentially reflecting thrombus-related heterogeneity. Combination therapy did not confer additional efficacy or safety benefits over antiplatelet or anticoagulant monotherapy.