Multi-dimensional evidence establishing the causal association between metabolic syndrome and gout and the molecular mechanisms of comorbidity

This study systematically established the causal association between MetS and gout through multi-dimensional evidence chains, revealing the molecular mechanism of comorbidity centered on antigen presentation-immune response and proposing a TAP2-UPR-Th17 pathological axis. These findings provide evidence-based support for early risk stratification and precision prevention of gout based on metabolic phenotypes.