Paclitaxel-induced germline DNA-damage signatures independent of mismatch repair in C. elegans

This integrated analysis establishes <i>C. elegans</i> as a tractable <i>in vivo</i> platform for dissecting both proliferative and meiotic consequences of paclitaxel. By linking spindle disruption, delayed DNA repair, and apoptosis with transcriptional reprogramming, the study provides mechanistic insight into germline vulnerability, reproductive side effects, and potential adaptive responses relevant to chemotherapy.