Causal Risk Factors for Type 1 Diabetes in Mendelian Randomization Studies: A Systematic Review and Meta-Analysis
This study systematically mapped the multi-omics causal risk landscape of T1DM, providing important evidence for precision prevention and targeted intervention. These findings suggest that targeting immune pathways (particularly IL2RA and TYK2) and modulating gut microbiota composition may represent promising strategies for T1DM prevention. Future research should emphasize cross-ethnic validation and life-stage-specific intervention strategies.
Authors
- Shichao Qiu (ORCID: https://orcid.org/0000-0002-6928-1061)
- Zhihua Wang (ORCID: https://orcid.org/0000-0001-6567-0759)
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Panting Shen
- Chao Liu
- Mali Li
Institutions
- Xi’an Children’s Hospital (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/dmso.s568784
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yakult Bio-Science Foundation