3D “Emboli” Culture Models Epithelial Breast Cancer Cell Oxidative Mitochondrial Metabolism with Relevance for Lung Metastasis
This study provides an in-depth characterization of a resource-efficient, yet powerful 3D culture paradigm to improve the physiologic relevance of ex vivo approaches. Applicable to epithelial cancers, this model offers a platform to accelerate the discovery of physiologically relevant signaling pathways and specific cancer cell vulnerabilities.
Authors
- Jonathan M. Weiss (ORCID: https://orcid.org/0000-0002-4467-5611)
- Melissa R. Mikolaj (ORCID: https://orcid.org/0000-0002-5452-1683)
- Ronald J. Holewinski (ORCID: https://orcid.org/0000-0002-3337-3984)
- Shiba Prasad Dash (ORCID: https://orcid.org/0000-0003-3388-0561)
- Lois McKennett
- Daoud Meerzaman (ORCID: https://orcid.org/0000-0002-0129-5256)
- Ariana Vitale
- Daniel W. McVicar (ORCID: https://orcid.org/0000-0002-1112-5111)
- Xin Chen (ORCID: https://orcid.org/0000-0002-5310-5426)
- Xia Xu
- Christopher W. Dell (ORCID: https://orcid.org/0000-0002-6563-697X)
- Esta Sterneck
- Shikha Sharan
- Shashikala Ratnayake
- Kuppusamy Balamurugan
- Yu Fan
- Duncan Donohue
- Thorkell Andresson
Institutions
- Leidos (United States) (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Data Management Services (United States) (US)
- Statistical Service (CY)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0587
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Frederick National Laboratory for Cancer Research
- Leidos
- National Cancer Institute