The myeloid SRC family kinase HCK regulates breast cancer growth by activating tumor-associated macrophage-led invasion and inhibiting cytotoxic T cell activity
This study provides evidence that HCK activity in TAMs enhances tumour growth via promotion of invasive behaviour as well as suppression of anti-tumor immunity. These findings highlight HCK as a promising therapeutic target to limit tumor progression.
Authors
- Yen Yeow (ORCID: https://orcid.org/0000-0002-2341-6354)
- Ashleigh R. Poh (ORCID: https://orcid.org/0000-0001-8375-4753)
- David A. Joyce (ORCID: https://orcid.org/0000-0002-7080-3293)
- Amy R. Dwyer (ORCID: https://orcid.org/0000-0002-4422-1433)
- Catherine Rinaldi (ORCID: https://orcid.org/0000-0003-4518-5638)
- James H. Steer
- Michael W. Murrey (ORCID: https://orcid.org/0000-0002-1000-8642)
- Fiona J. Pixley (ORCID: https://orcid.org/0000-0002-1571-2532)
- Lesley G. Ellies (ORCID: https://orcid.org/0000-0002-9298-4419)
- Matthias Ernst (ORCID: https://orcid.org/0000-0002-6399-1177)
- Kellie A. Mouchemore (ORCID: https://orcid.org/0000-0001-6329-3785)
- A P M Forrest
- Ya-Yu Liu (ORCID: https://orcid.org/0009-0008-4420-5178)
- Matthew E. Jones
- Irina Kuznetsova
- Khaing P. W. Hmon
- Weitao Lin
- Dáithí Ó Muirí
Institutions
- The University of Western Australia (AU)
- Harry Perkins Institute of Medical Research (AU)
- Olivia Newton-John Cancer Wellness & Research Centre (AU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1709102
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00