N‐Acetylglucosamine Selectively Attenuates Neuroinflammation in a Mouse Model of Mitochondrial Dysfunction
These findings define a temporal sequence of early glial activation, neuronal loss, and myelin alterations in mitochondrial encephalopathy. Targeting glial responses and neuroinflammation at early disease stages may mitigate neurodegenerative progression and improve functional outcomes, highlighting a physiologically relevant therapeutic window for mitochondrial disorders.
Authors
- Luis Alfredo Ávila López (ORCID: https://orcid.org/0000-0002-5391-2551)
- Enrica Olivieri (ORCID: https://orcid.org/0000-0002-8194-7751)
- Pilar González‐García (ORCID: https://orcid.org/0000-0002-9560-2957)
- Juan Manuel Martínez‐Gálvez
- Adriana L. Rojas
- Julia Corral‐Sarasa
- Carmen Venegas
- Janne Purhonen
- María Elena Díaz‐Casado
- Paula Ruiz‐López
- Sergio López‐Herrador
- Isaac Santos‐Pérez
- Laura Jiménez‐Sánchez
Institutions
- University of the Basque Country (ES)
- Universidad de Granada (ES)
- Karolinska Institutet (SE)
- CIC bioGUNE (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Fundación Biofísica Bizkaia (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1111/apha.70179
- Citations
- 1
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 30.63
Funders
- Sigrid Juséliuksen Säätiö
- Universidad de Granada
- Junta de Andalucía
- European Regional Development Fund
- Agencia Estatal de Investigación