Magnesium ions facilitate osteogenic differentiation and intervertebral fusion via m6A methylation of RhoA mRNA
This study provides an epigenetic framework for optimizing magnesium-based orthopedic implants and suggests that targeting the m6A-RhoA axis could improve spinal fusion outcomes.
Authors
- Zhiwen Luo (ORCID: https://orcid.org/0000-0003-1400-1437)
- Juan Wu (ORCID: https://orcid.org/0000-0002-1754-8465)
- Zhidi Lin (ORCID: https://orcid.org/0000-0002-6673-511X)
- Linli Li
- Zhicai Shi
- Xiaochuan Gu
- Dachuan Li
- Chenyan Li
- Feizhou Lyu
- Xinlei Xia
- Xiaosheng Ma
- Minghao Shao
- Haocheng Xu
- Fan Zhang
- Yitong Xue
- Zhaoyang Gong
- Xiao Lu
- Yang Liu
- Hongli Wang
Institutions
- Second Military Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- Changhai Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.jot.2026.101056
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00