Pathological complete response in microsatellite- stable gastric cancer with liver and bulky lymph node metastases after nivolumab-based chemotherapy and surgery: a case report
This case illustrates that even in MSS gastric cancer with low TMB levels, exceptionally high PD-L1 expression may predict a profound response to ICI-based therapy. The PD-L1 CPS may serve as a critical biomarker independent of TMB or microsatellite-instability status.
Authors
- Arizumi Kikuchi (ORCID: https://orcid.org/0000-0001-6010-8281)
- Chika Takao
- Yoshinori Mushika
- Koji Maniwa
- Minoru Komura
- Toshio Katô
- Noriyuki Takeuchi
- Mitsuhiko KUSAKABE
- Kenichi Nonaka
Institutions
- Daiyukai General Hospital (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1750532
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00