Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer (Adv. Sci. 10/2026)

Heating Cold Breast CanCers effeCtivelyThis cover art reimagines Investiture of the Gods.The Lady Shiji represents mTOR-driven immune evasion in triple-negative breast cancer (Skull Mountain).Nezha, representing a gold nanocomposite, strikes with his Spear (mTOR inhibitor) and Universe Ring (photothermal therapy), while Taiyi Zhenren (anti-PD-1) empowers T cells to attack Skull Mountain (tumor).This illustrates the strategy by Jing Jing, Xiaowei Liu, and co-workers to reverse immunosuppression and treat cold tumors.