Clinical Heterogeneity in Orthostatic Movement Disorders: Insights from Latent Class Analysis and Disease Burden Scoring
Multidomain clinical data enable disease-burden stratification and reveal phenotypic heterogeneity in orthostatic movement disorders. Limited correspondence with traditional diagnoses supports a spectrum-based model. DBS and LCA offer complementary frameworks for individualized assessment, warranting validation in larger and longitudinal cohorts.
Authors
- Michiko Kimura Bruno (ORCID: https://orcid.org/0000-0001-6575-424X)
- Anish Mehta
- Thyagarajan Shivashanmugam
- Pramod Kumar Pal
- Louis C.S. Tan
Institutions
- University of Hawaiʻi at Mānoa (US)
- Queen's Medical Center (US)
- National Neuroscience Institute (SG)
- M.S. Ramaiah Medical College (IN)
- Asha Foundation (IN)
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1002/mdc3.70563
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00