Milk fat globule—EGF factor 8/ATP‐binding cassette subfamily E member 1 axis maintains mitophagy flux homeostasis to suppress ferroptosis in acute pancreatitis
Endogenous MFG-E8 is downregulated in acute pancreatitis (AP), disrupting MFG-E8/ABCE1 complex formation. MFG-E8/ABCE1 axis sustains Parkin-PINK1-mediated mitophagy to clear damaged mitochondria in pancreatic acinar cells. This axis suppresses ferroptosis by reducing Fe<sup>2+</sup> accumulation and lipid peroxidation, alleviating AP-related pancreatic injury.
Authors
- Yun Sun (ORCID: https://orcid.org/0000-0002-2071-9114)
- Rongqian Wu
- Hongwei Lu
- Qing Cui
- Hao Shang
- Meng Fan
- Yifan Ren
- Xiali Shi
- Yuxuan Lu
Institutions
- Northwest University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/ctm2.70619
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00