Habitat radiomics based on CT for assessing BRCA mutation status in patients with high-grade serous ovarian cancer: a multicenter study

CT-based habitat radiomics offers a promising, non-invasive method for predicting BRCA mutation status in HGSOC. The combined habitat model outperformed traditional clinical and whole-tumor radiomic models by more effectively capturing tumor heterogeneity. SVM, demonstrating stable and reliable performance across datasets, emerged as the most robust model for clinical use. These findings support the integration of habitat radiomics, particularly SVM, for personalized, non-invasive molecular assessment in clinical practice.