Establishment of an induced pluripotent stem cell line from a patient with Leber Congenital Amaurosis
A human induced pluripotent stem cell (hiPSC) line BTHBIOi006-A was generated from peripheral blood mononuclear cells of a patient carrying RDH12 biallelic mutations via episomal reprogramming. The line exhibits a normal karyotype, expresses pluripotent markers, differentiates into three germ layers, and is mycoplasma-free, serving as a tool for retinal disease research.
Authors
- Zhihan Zhang (ORCID: https://orcid.org/0000-0002-1758-3914)
- Xiao-Hui Zhang
- Zi-Bing Jin
Institutions
- Beijing Tongren Hospital (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.scr.2026.103933
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00