Kinetics of antimalarial antibodies in children with common haemoglobinopathies in a Tanzanian population
These findings suggest that sickle cell trait may modulate PfEMP1 expression, thereby weakening the adhesion of <i>Plasmodium falciparum</i>-infected red blood cells to microvascular endothelial cells, while α⁺-thalassaemia may interfere with the shedding of parasite surface proteins involved in erythrocyte invasion. Collectively, these results provide further insight into the immunological and cellular mechanisms by which haemoglobinopathies confer protection against malaria.
Authors
- Christian W. Wang (ORCID: https://orcid.org/0000-0003-3140-6989)
- Arnold Ndaro
- Sixbert I. Mkumbaye (ORCID: https://orcid.org/0000-0001-8541-3848)
- Nuño Sepúlveda
- Eleanor M. Riley
- T. J. H. Clark
- Thor G. Theander
- Chris J. Drakeley
- Franklin W. Mosha
- Alphaxard Manjurano
- Louise Turner
- Kevin K.A. Tetteh
Institutions
- Warsaw University of Technology (PL)
- Rigshospitalet (DK)
- Clinical Research Institute (US)
- London School of Hygiene & Tropical Medicine (GB)
- Kilimanjaro Christian Medical Centre (TZ)
- National Institute for Medical Research (TZ)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1685626
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- London School of Hygiene and Tropical Medicine
- Leverhulme Trust