Single‐Cell RNAseq Identifies Heterogeneity in Myoblasts From Older Adults With Differences Related to Muscle Mass and Function
Our findings demonstrate considerable transcriptional heterogeneity in skeletal muscle myoblasts from older adults. This heterogeneity includes myoblasts from individuals with low muscle mass and strength progressing towards a fibrogenic or stressed state.
Authors
- Elie Antoun (ORCID: https://orcid.org/0000-0002-9477-1564)
- Karen A. Lillycrop (ORCID: https://orcid.org/0000-0001-7350-5489)
- Keith M. Godfrey (ORCID: https://orcid.org/0000-0002-4643-0618)
- Emma Garratt (ORCID: https://orcid.org/0000-0001-5268-4203)
- Matthew Hewitt (ORCID: https://orcid.org/0000-0001-8915-1996)
- Mark A. Burton (ORCID: https://orcid.org/0000-0002-7117-8151)
- Hanan Y. Sharkh
- Leo D Westbury
- Cyrus Cooper
- Harnish P. Patel
- Elaine M. Dennison
- Nicholas C. Harvey
Institutions
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Oxford (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- Oxford BioMedica (United Kingdom) (GB)
- MRC Lifecourse Epidemiology Unit (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/jcsm.70213
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00