Integrated single-cell analysis and mechanistic validation of LncRNA H19 in BMSC-mediated osteogenesis and potential implications for pain regulation
LncRNA H19 acts as a lineage-specific driver of osteogenic differentiation via the BMP2/NF-κB/Wnt5a axis. Targeting H19 represents a promising approach to promote bone regeneration and potentially modulate pathways associated with cancer-associated ostealgia.
Authors
- Qing Li
- Zhengguang Wang
- Hui Long
- Li Yuan
- Wei Gao
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1186/s40001-026-04083-8
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00